Use of Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Support Phase 2 and 3 Dosing Strategies for Doripenem

A doripenem population pharmacokinetic model and Monte Carlo simulations were utilized for dose regimen decision support for future clinical development. Simulation results predict that 500 mg of doripenem administered over 1 h every 8 h would be effective against bacterial strains with MICs less th...

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Bibliographic Details
Main Authors: Bhavnani, Sujata M., Hammel, Jeffrey P., Cirincione, Brenda B., Wikler, Matthew A., Ambrose, Paul G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Clinical Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195437/
https://ncbi.nlm.nih.gov/pubmed/16127078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3944-3947.2005
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