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A New ABC Half-Transporter in Leishmania major Is Involved in Resistance to Antimony

The characterization of ABCI4, a new intracellular ATP-binding cassette (ABC) half-transporter in Leishmania major, is described. We show that ABCI4 is involved in heavy metal export, thereby conferring resistance to Pentostam, to Sb(III), and to As(III) and Cd(II). Parasites overexpressing ABCI4 sh...

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Bibliografiske detaljer
Main Authors: Manzano, J. I., García-Hernández, R., Castanys, S., Gamarro, F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719772/
https://ncbi.nlm.nih.gov/pubmed/23716044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00211-13
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