HIV-1 Resistance Mechanism to an Electrostatically Constrained Peptide Fusion Inhibitor That Is Active against T-20-Resistant Strains

T-20EK is a novel fusion inhibitor designed to have enhanced α-helicity over T-20 (enfuvirtide) through engineered electrostatic interactions between glutamic acid (E) and lysine (K) substitutions. T-20EK efficiently suppresses wild-type and T-20-resistant variants. Here, we selected T-20EK-resistan...

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Bibliografiska uppgifter
Huvudupphovsmän: Shimane, Kazuki, Kawaji, Kumi, Miyamoto, Fusako, Oishi, Shinya, Watanabe, Kentaro, Sakagami, Yasuko, Fujii, Nobutaka, Shimura, Kazuya, Matsuoka, Masao, Kaku, Mitsuo, Sarafianos, Stefan G., Kodama, Eiichi N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2013
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719727/
https://ncbi.nlm.nih.gov/pubmed/23689710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00237-13
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