PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

Transposons are mobile DNA segments that can disrupt gene function by inserting in or near genes. Here we show that insertional mutagenesis by the PiggyBac transposon can be used for cancer gene discovery in mice. PiggyBac transposition in genetically engineered transposon/transposase mice induced c...

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Hlavní autoři: Rad, Roland, Rad, Lena, Wang, Wei, Cadinanos, Juan, Vassiliou, George, Rice, Stephen, Campos, Lia S., Yusa, Kosuke, Banerjee, Ruby, Li, Meng Amy, de la Rosa, Jorge, Strong, Alexander, Lu, Dong, Ellis, Peter, Conte, Nathalie, Yang, Fang Tang, Liu, Pentao, Bradley, Allan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719098/
https://ncbi.nlm.nih.gov/pubmed/20947725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1193004
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