Divergent effects of Sulforaphane on Basal and Glucose-Stimulated Insulin Secretion in β-Cells: Role of Reactive Oxygen Species and Induction of Endogenous Antioxidants

PURPOSE: Oxidative stress is implicated in pancreatic β-cell dysfunction, yet clinical outcomes of antioxidant therapies on diabetes are inconclusive. Since reactive oxygen species (ROS) can function as signaling intermediates for glucose-stimulated insulin secretion (GSIS), we hypothesize that exog...

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Main Authors: Fu, Jingqi, Zhang, Qiang, Woods, Courtney G., Zheng, Hongzhi, Yang, Bei, Qu, Weidong, Andersen, Melvin E., Pi, Jingbo
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718872/
https://ncbi.nlm.nih.gov/pubmed/23468051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1013-8
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