Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress

BACKGROUND: Chronic exposure of humans to inorganic arsenic, a potent environmental oxidative stressor, is associated with incidence of type 2 diabetes (T2D). A key driver in the pathogenesis of T2D is impairment of pancreatic β-cell function, with the hallmark of β-cell function being glucose-stimu...

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Main Authors: Fu, Jingqi, Woods, Courtney G., Yehuda-Shnaidman, Einav, Zhang, Qiang, Wong, Victoria, Collins, Sheila, Sun, Guifan, Andersen, Melvin E., Pi, Jingbo
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2010
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898865/
https://ncbi.nlm.nih.gov/pubmed/20100676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0901608
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