Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human Keratinocytes

Background: Nuclear factor E2-related factors (NRFs), including NRF2 and NRF1, play critical roles in mediating the cellular adaptive response to oxidative stress. Human exposure to inorganic arsenic, a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin can...

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Main Authors: Zhao, Rui, Hou, Yongyong, Zhang, Qiang, Woods, Courtney G., Xue, Peng, Fu, Jingqi, Yarborough, Kathy, Guan, Dawei, Andersen, Melvin E., Pi, Jingbo
Format: Artigo
Sprog:Inglês
Udgivet: National Institute of Environmental Health Sciences 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339469/
https://ncbi.nlm.nih.gov/pubmed/22476201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1104580
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