Inhibition of ERK1/2 Pathway Suppresses Adiponectin Secretion via Accelerating Protein Degradation by Ubiquitin-Proteasome System: Relevance to Obesity-related Adiponectin Decline

OBJECTIVE: Predominantly secreted by adipose tissue, adiponectin possesses insulin-sensitizing, anti-atherogenic, anti-inflammatory, and anti-angiogenic properties. Paradoxically, obesity is associated with declined plasma adiponectin levels; however, the underlying mechanisms remain elusive. In thi...

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Detalhes bibliográficos
Main Authors: Gu, Dongfang, Wang, Zhigang, Dou, Xiaobing, Zhang, Ximei, Li, Songtao, Vu, Lyndsey, Yao, Tong, Song, Zhenyuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718849/
https://ncbi.nlm.nih.gov/pubmed/23490586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2013.01.025
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