Biomarker Modulation Following Short Term Vorinostat in Women with Newly-Diagnosed Primary Breast Cancer

PURPOSE: Agents that target the epigenome demonstrate activity in breast cancer models. In preclinical studies, the histone deacetylase inhibitor vorinostat induces cell cycle arrest, apoptosis and differentiation. We evaluated biomarker modulation in breast cancer tissues obtained from women with n...

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Hauptverfasser: Stearns, Vered, Jacobs, Lisa K., Fackler, MaryJo, Tsangaris, Theodore N., Rudek, Michelle A., Higgins, Michaela, Lange, Julie, Cheng, Zandra, Slater, Shannon A., Jeter, Stacie C., Powers, Penny, Briest, Susanne, Chao, Calvin, Yoshizawa, Carl, Sugar, Elizabeth, Espinoza-Delgado, Igor, Sukumar, Saraswati, Gabrielson, Edward, Davidson, Nancy E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718062/
https://ncbi.nlm.nih.gov/pubmed/23719261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0033
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