Rhesus macaque KIR bind human MHC class I with broad specificity and recognize HLA-C more effectively than HLA-A and HLA-B

Ítems similars

• MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection
  per: Walter, Lutz, et al.
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• Natural variation at position 45 in the D1 domain of lineage III killer cell immunoglobulin-like receptors (KIR) has major effects on the avidity and specificity for MHC class I
  per: Older Aguilar, Anastazia M., et al.
  Publicat: (2011)
• Progression to AIDS in SIV-Infected Rhesus Macaques is Associated with Distinct KIR and MHC class I Polymorphisms and NK Cell Dysfunction
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• Humans differ from other hominids in lacking an activating NK cell receptor that recognizes the C1 Epitope of MHC class I
  per: Moesta, Achim K., et al.
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• KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A(*)11 while diminishing avidity for HLA-C
  per: Graef, Thorsten, et al.
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