Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice

The Ca(2+)-activated K(+) channel KCa3.1 mediates cellular signaling processes associated with dysfunction of vasculature. However, the role of KCa3.1 in diabetic nephropathy is unknown. We sought to assess whether KCa3.1 mediates the development of renal fibrosis in two animal models of diabetic ne...

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Main Authors: Huang, Chunling, Shen, Sylvie, Ma, Qing, Chen, Jason, Gill, Anthony, Pollock, Carol A., Chen, Xin-Ming
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2013
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717839/
https://ncbi.nlm.nih.gov/pubmed/23656889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0135
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