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Population Pharmacokinetics of Phenobarbital in Infants with Neonatal Encephalopathy treated with Therapeutic Hypothermia

OBJECTIVE: Phenobarbital is the first-line treatment for neonatal seizures. Many neonates with hypoxic ischemic encephalopathy (HIE) are treated with therapeutic hypothermia (TH) and about 40% have clinical seizures. Little is known about pharmacokinetics of phenobarbital in infants with HIE who und...

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Detalhes bibliográficos
Main Authors: Shellhaas, Renée A., Ng, Chee M, Dillon, Christina H., Barks, John D.E., Bhatt-Mehta, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717607/
https://ncbi.nlm.nih.gov/pubmed/23254984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PCC.0b013e31825bbbc2
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