The Fractalkine/CX3CR1 System Regulates Beta Cell Function and Insulin Secretion

Here, we demonstrate that the fractalkine(FKN)/CX3CR1 system represents a previously undescribed regulatory mechanism for pancreatic islet beta cell function and insulin secretion. CX3CR1 KO mice exhibited a marked defect in glucose and GLP1-stimulated insulin secretion, and this defect was also obs...

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Main Authors: Lee, Yun Sok, Morinaga, Hidetaka, Kim, Jane J., Lagakos, William, Taylor, Susan, Keshwani, Malik, Perkins, Guy, Dong, Hui, Kayali, Ayse G., Sweet, Ian R., Olefsky, Jerrold
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717389/
https://ncbi.nlm.nih.gov/pubmed/23582329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.03.001
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