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Early trauma hemorrhage-induced splenic and thymic apoptosis is gut-mediated and TLR4-dependent

Immune depression after trauma-hemorrhage has been implicated as an important factor in the pathogenesis of sepsis and septic-organ failure. Although recent studies have implicated immune cell apoptosis as an important factor in the evolution of this post-trauma immune suppressed state, neither the...

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Detalhes bibliográficos
Main Authors: Tiesi, Gregory, Reino, Diego, Mason, Leonard, Palange, David, Tomaio, Jacquelyn N., Deitch, Edwin A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717364/
https://ncbi.nlm.nih.gov/pubmed/23542401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e318293d020
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