Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screening each line for a broad range of traits. We found that h...

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Main Authors: White, Jacqueline K., Gerdin, Anna-Karin, Karp, Natasha A., Ryder, Ed, Buljan, Marija, Bussell, James N., Salisbury, Jennifer, Clare, Simon, Ingham, Neil J., Podrini, Christine, Houghton, Richard, Estabel, Jeanne, Bottomley, Joanna R., Melvin, David G., Sunter, David, Adams, Niels C., Tannahill, David, Logan, Darren W., MacArthur, Daniel G., Flint, Jonathan, Mahajan, Vinit B., Tsang, Stephen H., Smyth, Ian, Watt, Fiona M., Skarnes, William C., Dougan, Gordon, Adams, David J., Ramirez-Solis, Ramiro, Bradley, Allan, Steel, Karen P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717207/
https://ncbi.nlm.nih.gov/pubmed/23870131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.022
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