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Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

BACKGROUND: The adipokine leptin and its receptor are expressed in the heart, and leptin has been shown to promote cardiomyocyte hypertrophy in vitro. Obesity is associated with hyperleptinemia and hypothalamic leptin resistance as well as an increased risk to develop cardiac hypertrophy and heart f...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Leifheit-Nestler, Maren, Wagner, Nana-Maria, Gogiraju, Rajinikanth, Didié, Michael, Konstantinides, Stavros, Hasenfuss, Gerd, Schäfer, Katrin
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717024/
https://ncbi.nlm.nih.gov/pubmed/23841921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-170
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