Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

BACKGROUND: The adipokine leptin and its receptor are expressed in the heart, and leptin has been shown to promote cardiomyocyte hypertrophy in vitro. Obesity is associated with hyperleptinemia and hypothalamic leptin resistance as well as an increased risk to develop cardiac hypertrophy and heart f...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Leifheit-Nestler, Maren, Wagner, Nana-Maria, Gogiraju, Rajinikanth, Didié, Michael, Konstantinides, Stavros, Hasenfuss, Gerd, Schäfer, Katrin
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2013
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717024/
https://ncbi.nlm.nih.gov/pubmed/23841921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-170
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