Activated Endothelial TGFβ1 Signaling Promotes Venous Thrombus Non-Resolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension

RATIONALE: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by defective thrombus resolution, pulmonary artery obstruction and vasculopathy. Transforming growth factor-beta (TGFβ) signaling mutations have been implicated in pulmonary arterial hypertension, whereas TGFβ’s role i...

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Publicado no:Circ Res
Main Authors: Bochenek, Magdalena L., Leidinger, Christiane, Rosinus, Nico S., Gogiraju, Rajinikanth, Guth, Stefan, Hobohm, Lukas, Jurk, Kerstin, Mayer, Eckhard, Münzel, Thomas, Lankeit, Mareike, Bosmann, Markus, Konstantinides, Stavros, Schäfer, Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101077/
https://ncbi.nlm.nih.gov/pubmed/31747868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315259
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