Leptin Enhances the Potency of Circulating Angiogenic Cells via Src Kinase and Integrin αvβ5: Implications for Angiogenesis in Human Obesity

OBJECTIVE: The present study investigated the capacity of the adipokine leptin to promote angiogenesis by modulating the function of circulating angiogenic cells (CAC). METHODS AND RESULTS: In vitro, leptin specifically promoted CAC adhesion to tubular endothelial structures and migration along outg...

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Hauptverfasser: Heida, Nana-Maria, Leifheit-Nestler, Maren, Schroeter, Marco R., Müller, Jan-Peter, Cheng, I-Fen, Henkel, Sarah, Limbourg, Anne, Limbourg, Florian P., Alves, Frauke, Quigley, James P., Ruggeri, Zaverio M., Hasenfuss, Gerd, Konstantinides, Stavros, Schäfer, Katrin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824857/
https://ncbi.nlm.nih.gov/pubmed/19910644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.192807
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