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Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering

The polyketide synthase (PKS) biosynthetic code has recently expanded to include a newly recognized group of extender unit substrates derived from α,β-unsaturated acyl-CoA molecules that deliver diverse side chain chemistry to polyketide backbones. Herein we report the identification of a three-gene...

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Detalhes bibliográficos
Main Authors: Lechner, Anna, Wilson, Micheal C., Ban, Yeon Hee, Hwang, Jae-yeon, Yoon, Yeo Joon, Moore, Bradley S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716868/
https://ncbi.nlm.nih.gov/pubmed/23654255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/sb3001062
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