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Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering
The polyketide synthase (PKS) biosynthetic code has recently expanded to include a newly recognized group of extender unit substrates derived from α,β-unsaturated acyl-CoA molecules that deliver diverse side chain chemistry to polyketide backbones. Herein we report the identification of a three-gene...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3716868/ https://ncbi.nlm.nih.gov/pubmed/23654255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/sb3001062 |
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