Roles of fkbN in Positive Regulation and tcs7 in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP

FK506 is an important 23-member polyketide macrolide with immunosuppressant activity. Its entire biosynthetic gene cluster was previously cloned from Streptomyces sp. strain KCTC 11604BP, and sequence analysis identified three putative regulatory genes, tcs2, tcs7, and fkbN, which encode proteins wi...

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Autores principales: Mo, SangJoon, Yoo, Young Ji, Ban, Yeon Hee, Lee, Sung-Kwon, Kim, Eunji, Suh, Joo-Won, Yoon, Yeo Joon
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Biotechnology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302593/
https://ncbi.nlm.nih.gov/pubmed/22267670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.06766-11
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