FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

BACKGROUND: FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species. Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis. Regulatory elements, pr...

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Bibliografische gegevens
Hoofdauteurs: Goranovič, Dušan, Blažič, Marko, Magdevska, Vasilka, Horvat, Jaka, Kuščer, Enej, Polak, Tomaž, Santos-Aberturas, Javier, Martínez-Castro, Miriam, Barreiro, Carlos, Mrak, Peter, Kopitar, Gregor, Kosec, Gregor, Fujs, Štefan, Martín, Juan F, Petković, Hrvoje
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551636/
https://ncbi.nlm.nih.gov/pubmed/23083511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-12-238
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