FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

BACKGROUND: FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species. Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis. Regulatory elements, pr...

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Main Authors: Goranovič, Dušan, Blažič, Marko, Magdevska, Vasilka, Horvat, Jaka, Kuščer, Enej, Polak, Tomaž, Santos-Aberturas, Javier, Martínez-Castro, Miriam, Barreiro, Carlos, Mrak, Peter, Kopitar, Gregor, Kosec, Gregor, Fujs, Štefan, Martín, Juan F, Petković, Hrvoje
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551636/
https://ncbi.nlm.nih.gov/pubmed/23083511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-12-238
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