FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

BACKGROUND: FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species. Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis. Regulatory elements, pr...

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Главные авторы: Goranovič, Dušan, Blažič, Marko, Magdevska, Vasilka, Horvat, Jaka, Kuščer, Enej, Polak, Tomaž, Santos-Aberturas, Javier, Martínez-Castro, Miriam, Barreiro, Carlos, Mrak, Peter, Kopitar, Gregor, Kosec, Gregor, Fujs, Štefan, Martín, Juan F, Petković, Hrvoje
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551636/
https://ncbi.nlm.nih.gov/pubmed/23083511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-12-238
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