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Assembly of Four Diverse Heterocyclic Libraries Enabled by Prins Cyclization, Au-Catalyzed Enyne Cycloisomerization, and Automated Amide Synthesis

[Image: see text] We describe a unified synthetic strategy for efficient assembly of four new heterocyclic libraries. The synthesis began by creating a range of structurally diverse pyrrolidinones or piperidinones. Such compounds were obtained in a simple one-flask operation starting with readily av...

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Autors principals: Cui, Jiayue, Chai, David I., Miller, Christopher, Hao, Jason, Thomas, Christopher, Wang, JingQi, Scheidt, Karl A., Kozmin, Sergey A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716468/
https://ncbi.nlm.nih.gov/pubmed/22860634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo301061r
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