Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment

Mesenchymal stromal cells (MSCs) are a major component of the leukemia bone marrow (BM) microenvironment. Connective tissue growth factor (CTGF) is highly expressed in MSCs, but its role in the BM stroma is unknown. Therefore, we knocked down (KD) CTGF expression in human BM-derived MSCs by CTGF sho...

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Detalhes bibliográficos
Main Authors: Battula, V. Lokesh, Chen, Ye, Cabreira, Maria da Graca, Ruvolo, Vivian, Wang, Zhiqiang, Ma, Wencai, Konoplev, Sergej, Shpall, Elizabeth, Lyons, Karen, Strunk, Dirk, Bueso-Ramos, Carlos, Davis, Richard Eric, Konopleva, Marina, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716201/
https://ncbi.nlm.nih.gov/pubmed/23741006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-437988
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