Heteroresistance to Fosfomycin Is Predominant in Streptococcus pneumoniae and Depends on the murA1 Gene

Fosfomycin targets the first step of peptidoglycan biosynthesis in Streptococcus pneumoniae catalyzed by UDP-N-acetylglucosamine enolpyruvyltransferase (MurA1). We investigated whether heteroresistance to fosfomycin occurs in S. pneumoniae. We found that of 11 strains tested, all but 1 (Hungary(19A)...

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Autores principales: Engel, Hansjürg, Gutiérrez-Fernández, Javier, Flückiger, Christine, Martínez-Ripoll, Martín, Mühlemann, Kathrin, Hermoso, Juan A., Hilty, Markus, Hathaway, Lucy J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716182/
https://ncbi.nlm.nih.gov/pubmed/23571543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00223-13
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