Structural Determinants of the Capacity of Heparin to Inhibit the Formation of the Human Amplification C3 Convertase

The ability of heparin glycosaminoglycan to prevent formation of the properdin-stabilized amplification C3 convertase is independent of antithrombin binding activity and requires substitution of the amino sugar and a degree of oxygen (O)-sulfation which could be on the uronic acid or the amino sugar...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Kazatchkine, Michel D., Fearon, Douglas T., Metcalfe, Dean D., Rosenberg, Robert D., Austen, K. Frank
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1981
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371591/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6778897/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110017
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