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Structural Determinants of the Capacity of Heparin to Inhibit the Formation of the Human Amplification C3 Convertase

The ability of heparin glycosaminoglycan to prevent formation of the properdin-stabilized amplification C3 convertase is independent of antithrombin binding activity and requires substitution of the amino sugar and a degree of oxygen (O)-sulfation which could be on the uronic acid or the amino sugar...

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Autori principali: Kazatchkine, Michel D., Fearon, Douglas T., Metcalfe, Dean D., Rosenberg, Robert D., Austen, K. Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1981
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC371591/
https://ncbi.nlm.nih.gov/pubmed/6778897
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