Crystal structure of constitutively active rhodopsin: How an agonist can activate its GPCR

G protein-coupled receptors (GPCRs) comprise the largest family of membrane proteins in the human genome and mediate cellular responses to an extensive array of hormones, neurotransmitters, and sensory stimuli. While some crystal structures have been determined for GPCRs, most are for modified forms...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Standfuss, Jörg, Edwards, Patricia C., D’Antona, Aaron, Fransen, Maikel, Xie, Guifu, Oprian, Daniel D., Schertler, Gebhard F. X.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715716/
https://ncbi.nlm.nih.gov/pubmed/21389983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09795
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