Targeting Natural Killer cells to Acute Myeloid Leukemia in vitro with a CD16x33 bispecific killer cell engager (BiKE) and ADAM17 inhibition

PURPOSE: The graft versus leukemia (GVL) effect by Natural Killer (NK) cells prevents relapse following hematopoietic stem cell transplantation. We determined whether a novel bi-specific killer cell engager (BiKE) signaling through CD16 and targeting CD33 could activate NK cells at high potency agai...

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Hauptverfasser: Wiernik, Andres, Foley, Bree, Zhang, Bin, Verneris, Michael R., Warlick, Erica, Gleason, Michelle K., Ross, Julie A., Luo, Xianghua, Weisdorf, Daniel J., Walcheck, Bruce, Vallera, Daniel A, Miller, Jeffrey S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715574/
https://ncbi.nlm.nih.gov/pubmed/23690482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0505
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