4-hydroxy-tamoxifen induces autophagic death through K-Ras degradation

Tamoxifen is widely used to treat estrogen receptor (ER)-positive breast cancer. Recent findings that tamoxifen and its derivative 4-dehydroxy-tamoxifen (OHT) can exert ER-independent cytotoxic effects have prompted the initiation of clinical trials to evaluate its use in ER-negative malignancies. F...

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Bibliografiset tiedot
Päätekijät: Kohli, Latika, Kaza, Niroop, Coric, Tatjana, Byer, Stephanie J., Brossier, Nicole M., Klocke, Barbara J., Bjornsti, Mary-Ann, Carroll, Steven L., Roth, Kevin A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715566/
https://ncbi.nlm.nih.gov/pubmed/23722551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3765
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