The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State

The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila melanogaster, we carried out an overexpression screen for oncogenes capable of cooperating with the loss of the...

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Autori principali: Turkel, Nezaket, Sahota, Virender K., Bolden, Jessica E., Goulding, Karen R., Doggett, Karen, Willoughby, Lee F., Blanco, Enrique, Martin-Blanco, Enrique, Corominas, Montserrat, Ellul, Jason, Aigaki, Toshiro, Richardson, Helena E., Brumby, Anthony M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715428/
https://ncbi.nlm.nih.gov/pubmed/23874226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003627
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