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Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8(+) T-Cell Exhaustion
The type I interferons (IFN-Is) are critical not only in early viral control but also in prolonged T-cell immune responses. However, chronic viral infections such as those of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) in humans and lymphocytic choriomeningitis virus (LCMV) in mic...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3715418/ https://ncbi.nlm.nih.gov/pubmed/23874199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003478 |
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