Juxtaposition of chemical and mutation- induced developmental defects in zebrafish reveal a novel copper-chelating activity for kalihinol F

A major hurdle in using complex systems for drug screening is the difficulty of defining the mechanistic targets of small molecules. The zebrafish provides an excellent model system for juxtaposing developmental phenotypes with mechanism discovery using organism genetics. We carried out a phenotype-...

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Main Authors: Sandoval, Imelda T., Manos, Elizabeth J., Van Wagoner, Ryan M., Delacruz, Richard Glenn C., Edes, Kornelia, Winge, Dennis R., Ireland, Chris M., Jones, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715381/
https://ncbi.nlm.nih.gov/pubmed/23790486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.05.008
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