Thyrotropin-releasing Hormone Stimulation of Adrenocorticotropin Production by Mouse Pituitary Tumor Cells in Culture: POSSIBLE MODEL FOR ANOMALOUS RELEASE OF ADRENOCORTICOTROPIN BY THYROTROPIN-RELEASING HORMONE IN SOME PATIENTS WITH CUSHING'S DISEASE AND NELSON'S SYNDROME

ACTH-producing mouse pituitary tumor cells in culture (AtT-20/NYU-1 cells) were found to have binding sites for thyrotropin-releasing hormone (TRH). These putative receptors bound TRH with high affinity; the apparent equilibrium dissociation constant was 3.7 nM. The affinity of the receptors for a s...

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Main Authors: Gershengorn, Marvin C., Arevalo, Carlos O., Geras, Elizabeth, Rebecchi, Mario J.
Format: Artigo
Sprog:Inglês
Udgivet: 1980
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC371466/
https://ncbi.nlm.nih.gov/pubmed/6251109
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