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Thyrotropin-releasing Hormone Stimulation of Adrenocorticotropin Production by Mouse Pituitary Tumor Cells in Culture: POSSIBLE MODEL FOR ANOMALOUS RELEASE OF ADRENOCORTICOTROPIN BY THYROTROPIN-RELEASING HORMONE IN SOME PATIENTS WITH CUSHING'S DISEASE AND NELSON'S SYNDROME
ACTH-producing mouse pituitary tumor cells in culture (AtT-20/NYU-1 cells) were found to have binding sites for thyrotropin-releasing hormone (TRH). These putative receptors bound TRH with high affinity; the apparent equilibrium dissociation constant was 3.7 nM. The affinity of the receptors for a s...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1980
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC371466/ https://ncbi.nlm.nih.gov/pubmed/6251109 |
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