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Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation

Eukaryotic cells maintain strict control over protein secretion, in part by using the pH gradient maintained within their secretory pathway. How eukaryotic proteins evolved from prokaryotic orthologs to exploit the pH gradient for biological functions remains a fundamental question in cell biology....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Elferich, Johannes, Williamson, Danielle M., Krishnamoorthy, Bala, Shinde, Ujwal
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Federation of American Societies for Experimental Biology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714588/
https://ncbi.nlm.nih.gov/pubmed/23585398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-226886
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