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Identification of a pH Sensor in the Furin Propeptide That Regulates Enzyme Activation
The folding and activation of furin occur through two pH- and compartment-specific autoproteolytic steps. In the endoplasmic reticulum (ER), profurin folds under the guidance of its prodomain and undergoes an autoproteolytic excision at the consensus furin site Arg-Thr-Lys-Arg(107) ↓ generating an e...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4293020/ https://ncbi.nlm.nih.gov/pubmed/16601116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M600760200 |
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