Genome- and Phenome-Wide Analysis of Cardiac Conduction Identifies Markers of Arrhythmia Risk

BACKGROUND: Electrocardiographic QRS duration, a measure of cardiac intraventricular conduction, varies ~2-fold in individuals without cardiac disease. Slow conduction may promote reentrant arrhythmias. METHODS AND RESULTS: We performed a genome-wide association study (GWAS) to identify genomic mark...

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Main Authors: Ritchie, Marylyn D., Denny, Joshua C., Zuvich, Rebecca L., Crawford, Dana C., Schildcrout, Jonathan S., Bastarache, Lisa, Ramirez, Andrea H., Mosley, Jonathan D., Pulley, Jill M., Basford, Melissa A., Bradford, Yuki, Rasmussen, Luke V., Pathak, Jyotishman, Chute, Christopher G., Kullo, Iftikhar J., McCarty, Catherine A., Chisholm, Rex L., Kho, Abel N., Carlson, Christopher S., Larson, Eric B., Jarvik, Gail P., Sotoodehnia, Nona, Manolio, Teri A., Li, Rongling, Masys, Daniel R., Haines, Jonathan L., Roden, Dan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713791/
https://ncbi.nlm.nih.gov/pubmed/23463857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.000604
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