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A Single D(H) Gene Segment Is Sufficient for the Establishment of an Asthma Phenotype in a Murine Model of Allergic Airway Inflammation

BACKGROUND: We have previously shown that the allergic sensitization to ovalbumin does not represent a superantigen-like immune response. In gene-targeted mice (ΔD-iD) with a single modified Diversity gene segment (D(H)) of the immunoglobulin heavy chain, enriched for charged amino acids, the asthma...

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Detalhes bibliográficos
Main Authors: Kerzel, Sebastian, Rogosch, Tobias, Wagner, Julia, Preisser, Kathrin, Yildirim, Ali-Önder, Fehrenbach, Heinz, Garn, Holger, Maier, Rolf F., Schroeder, Harry W., Zemlin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713642/
https://ncbi.nlm.nih.gov/pubmed/21720170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000323527
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