Composition of the immunoglobulin classic antigen-binding site regulates allergic airway inflammation in a murine model of experimental asthma

BACKGROUND: When bound to mast cell FcεRI, IgE serves as antigen receptor for allergic reactions, permitting specific identification of the allergen. Although the core of the classic antigen-binding site is heavy chain complementarity determining region 3 (CDR-H3), recent studies suggest that allerg...

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Main Authors: Kerzel, Sebastian, Wagner, Julia, Rogosch, Tobias, Yildirim, Ali-Önder, Sikula, Larisa, Fehrenbach, Heinz, Garn, Holger, Maier, Rolf F., Schroeder, Harry W., Zemlin, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681526/
https://ncbi.nlm.nih.gov/pubmed/19220320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2222.2008.03178.x
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