Dependency of cyclic AMP-induced insulin release on intra- and extracellular calcium in rat islets of Langerhans.

Calcium and cyclic AMP are important in the stimulation of insulin release. The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) raises islet cAMP levels and causes insulin release at nonstimulatory glucose concentrations. In isolated rat pancreatic islets maintained for 2 d in tissue...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Siegel, E G, Wollheim, C B, Kikuchi, M, Renold, A E, Sharp, G W
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 1980
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371360/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6153182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109665
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