Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

p53 mutations and downregulation of promyelocytic leukemia (PML) are common genetic alterations in human cancers. In healthy cells these two key tumor suppressors exist in a positive regulatory loop, promoting cell death and cellular senescence. However, the influence of their interplay on tumorigen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Haupt, Sue, Mitchell, Catherine, Corneille, Vincent, Shortt, Jake, Fox, Stephen, Pandolfi, Pier Paolo, Castillo-Martin, Mireia, Bonal, Dennis M., Cordon-Cardo, Carlos, Lozano, Guillermina, Haupt, Ygal
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713131/
https://ncbi.nlm.nih.gov/pubmed/23656786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24805
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge