Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

p53 mutations and downregulation of promyelocytic leukemia (PML) are common genetic alterations in human cancers. In healthy cells these two key tumor suppressors exist in a positive regulatory loop, promoting cell death and cellular senescence. However, the influence of their interplay on tumorigen...

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Detalhes bibliográficos
Main Authors: Haupt, Sue, Mitchell, Catherine, Corneille, Vincent, Shortt, Jake, Fox, Stephen, Pandolfi, Pier Paolo, Castillo-Martin, Mireia, Bonal, Dennis M., Cordon-Cardo, Carlos, Lozano, Guillermina, Haupt, Ygal
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713131/
https://ncbi.nlm.nih.gov/pubmed/23656786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24805
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