RNA Polymerase I Stability Couples Cellular Growth to Metal Availability

Zinc is an essential cofactor of all major eukaryotic RNA polymerases. How the activity of these enzymes is coordinated or regulated according to cellular zinc levels is largely unknown. Here we show that the stability of RNA Polymerase I (RNAPI) is tightly coupled to zinc availability in vivo. In z...

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Библиографические подробности
Главные авторы: Lee, Yueh-Jung, Lee, Chrissie Young, Grzechnik, Agnieszka, Gonzales-Zubiate, Fernando, Vashisht, Ajay A., Lee, Albert, Wohlschlegel, James, Chanfreau, Guillaume
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713077/
https://ncbi.nlm.nih.gov/pubmed/23747013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.005
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