RNA Polymerase I Stability Couples Cellular Growth to Metal Availability

Zinc is an essential cofactor of all major eukaryotic RNA polymerases. How the activity of these enzymes is coordinated or regulated according to cellular zinc levels is largely unknown. Here we show that the stability of RNA Polymerase I (RNAPI) is tightly coupled to zinc availability in vivo. In z...

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Detalhes bibliográficos
Main Authors: Lee, Yueh-Jung, Lee, Chrissie Young, Grzechnik, Agnieszka, Gonzales-Zubiate, Fernando, Vashisht, Ajay A., Lee, Albert, Wohlschlegel, James, Chanfreau, Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713077/
https://ncbi.nlm.nih.gov/pubmed/23747013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.005
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