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Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression

The human AP-endonuclease (APE1/Ref-1), an essential multifunctional protein involved in repair of oxidative DNA damage as well as in transcriptional regulation, is often overexpressed in tumor cells. APE1 was earlier shown to stimulate p53’s DNA binding and its transactivation function in the expre...

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Detalhes bibliográficos
Main Authors: Sengupta, Shiladitya, Mitra, Sankar, Bhakat, Kishor K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713036/
https://ncbi.nlm.nih.gov/pubmed/23874636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068467
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