Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

We previously described a heterozygous mouse model overexpressing human HA-tagged 24S-hydroxylase (CYP46A1) utilizing a ubiquitous expression vector. In this study, we generated homozygotes of these mice with circulating levels of 24OH 30–60% higher than the heterozygotes. Female homozygous CYP46A1...

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Main Authors: Maioli, Silvia, Båvner, Ann, Ali, Zeina, Heverin, Maura, Ismail, Muhammad-Al-Mustafa, Puerta, Elena, Olin, Maria, Saeed, Ahmed, Shafaati, Marjan, Parini, Paolo, Cedazo-Minguez, Angel, Björkhem, Ingemar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712995/
https://ncbi.nlm.nih.gov/pubmed/23874659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068534
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