On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(−/−) mice(1)

The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is controversial, however. In the present work, we u...

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Autores principales: Ali, Zeina, Heverin, Maura, Olin, Maria, Acimovic, Jure, Lövgren-Sandblom, Anita, Shafaati, Marjan, Båvner, Ann, Meiner, Vardiella, Leitersdorf, Eran, Björkhem, Ingemar
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605980/
https://ncbi.nlm.nih.gov/pubmed/23284090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M034124
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