Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

Animal studies generate valuable hypotheses that lead to the conduct of preventive or therapeutic clinical trials. We assessed whether there is evidence for excess statistical significance in results of animal studies on neurological disorders, suggesting biases. We used data from meta-analyses of i...

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Autors principals: Tsilidis, Konstantinos K., Panagiotou, Orestis A., Sena, Emily S., Aretouli, Eleni, Evangelou, Evangelos, Howells, David W., Salman, Rustam Al-Shahi, Macleod, Malcolm R., Ioannidis, John P. A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712913/
https://ncbi.nlm.nih.gov/pubmed/23874156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001609
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