Effect of Cytochrome P450 3A5 Genotype on Atorvastatin Pharmacokinetics and Its Interaction with Clarithromycin

STUDY OBJECTIVE: To assess the effects of the cytochrome P450 (CYP) 3A genotype, CYP3A5, on atorvastatin pharmacokinetics and its interaction with clarithromycin. DESIGN: Prospective, two-phase, randomized-sequence, open-label pharmacokinetic study. SETTING: Clinical research center at a teaching ho...

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Bibliografiske detaljer
Main Authors: Shin, Jaekyu, Pauly, Daniel F., Pacanowski, Michael A., Langaee, Taimour, Frye, Reginald F., Johnson, Julie A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712822/
https://ncbi.nlm.nih.gov/pubmed/21950641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1592/phco.31.10.942
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