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Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes

Little direct information is available regarding the influence of membrane environment on transmembrane (TM) G-protein-coupled receptor (GPCR) conformation and dynamics. The human CB1 cannabinoid receptor (hCB1) is a prominent GPCR pharmacotherapeutic target in which helix 7 appears critical to liga...

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Bibliografiske detaljer
Main Authors: Tiburu, Elvis K., Bowman, Anna L., Struppe, Jochem O., Janero, David R., Avraham, Hava K., Makriyannis, Alexandros
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712639/
https://ncbi.nlm.nih.gov/pubmed/19366584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2009.02.002
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