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The diabetic β-cell: hyperstimulated vs. hyperexcited
Hyperglycaemia has multiple effects on β-cells, some clearly prosecretory, including hyperplasia and elevated insulin content, but eventually, a ‘glucotoxic’ effect which leads to pancreatic β-cell dysfunction, reduced β-cell mass and insulin deficiency, is an important part of diabetes pathophysiol...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712635/ https://ncbi.nlm.nih.gov/pubmed/22928573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1463-1326.2012.01655.x |
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